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Biomarkers
Clinically relevant markers of drug efficacy or safety
- Biomarker discovery and validation
- New markers for slow, progressive diseases
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Clinically Relevant Targets
Approaches to demonstrate clinical validity of drug targets or pathways
- Validation of novel, clinically relevant target classes
- Superior in vivo models
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Customized Treatments
Platforms enabling personalized medicine
- Broad platforms for patient stratification
- Biomarker identification in point-of-care setting
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Drug Delivery
Advancements in delivery to specific tissues or organs, or of new molecule classes
- Non-parenteral delivery of biologics
- Selective agents for tissue-specific delivery
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Drug Safety
Better means for understanding and predicting toxicity
- Clinically predictive models of adverse outcomes
- Safety marker identification
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Systems Biology
Approaches that enable an integrated view of biology
- Platforms for large-scale phenotypic screening
- Large scale data processing and analysis
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New Chemistries & Therapeutic Modalities
Improved therapeutic capabilities from novel molecular structures
- Novel molecular forms enabling new therapeutic approaches
- Superior methods of molecular construction and design
